If you're worried that taking a prescription drug off-label sounds shady, don't be. Not all drugs have off-label purposes, and those that do are selected are chosen for specific reasons. "The positive side of off-label drug use is the expanded clinical utility of a drug," Thaler says. Many doctors believe prescribing a drug off-label can result in big benefits, but there are definite risks and consequences to consider as well. Keep reading to learn about five of the most commonly prescribed off-label drugs.